Originally Posted by fostot
Does that mean that there are no layouts for say like 1920x1080 that will put things in the correct location for us? :P
There are no preset layouts, since everyone has their own idea of what works best for them. DarqUI custom windows are generally the same size as their default counterparts, so the transition from Default to DarqUI should be a smooth one for the normal-size UI. If you are using the large version there will be a little bit of adjusting on the persistent components -- Player, Target, Implied Target, etc.
If things seem really out of control, you can try Pijotre's suggestion to reset.