eq2 map "denied" error?

[kiny]

for some reason all of a sudden im getting a red error message in eq2 map window saying :- "Access to the path C:\users\dave\appdata\local\eq2mqp\cache\manifest_list.xml" is denied.
whats is this please as it wont update now?
I have also uninstalled and re-instaled it
much appreciated
K....