I originally used Thor b/c of the auto-updater but in reality it wasn't updated all that often so I searched out a new UI and fell in love with Profit.
When you download the zip file, extract it to c:\program files\sony\everquest 2\ (or where ever it is saved). The zip file will automatically distribute the files into the proper folders.
Each update doesnt need to be installed as well usually. I often go 3-4 releases before downloading them, but process is still the same and quite painless as your character INI files saves the location of the windows and hotkeys.
When you go into game then /loadui to choose Profit.
(edit by gm9: he means /load_uisettings, forget that you heard about /loadui ) Then choose the resolution you are running and it will pretty much be set up. For me that is much more convenient then an auto-updater as I spent forever getting my thor windows configured hehe.
Post up if you need some more help!