a couple of ways you could do it.
1. copy the profitui folder so you have 2. then extract the horizontal g/w into one of them.
have 2 different eq2.ini files pointing to each folder.
then just rename them when the other wants to play (dos batch files can be used to do this, and launch eq)
2. have 2 different g/w eg eq2ui_mainhud_his_groupmembers.xml and eq2ui_mainhud_her_groupmembers.xml rename when the other wants to play.
again dos can used to perform this. Only thing with this option is, you will have to reposition the g/w when changed.
Probably how your doing it now......
3. the best , if you have the drive space. -- a bit much just to have 1 file different, i know
copy the entire Everquest2 folder (8gig plus)
then create a second shortcut on desktop to second eq2.exe
This way, you have 2 totally different eq2's, so you can change what you want, without affecting the other.