I am currently running Windows 7 Home Edition x64. I have not had problems getting EQ2Maps to work at all. I am using the auto updating version of EQ2Maps. I'm not sure what if any software prerequisites are required for the updater to work. But I just installed it and ran with it. The most you might have to worry about is running the program with elevated privileges, but that can be accomplished with a right click and set to happen automatically with just a few clicks after that.
Also might want to read the Read First Post in the EQ2Map specific forum (the forum you've posted in). It may help you to avoid problems before they even start.
http://www.eq2interface.com/forums/s...ead.php?t=3203
Hope that helps assuage some of your concerns.