You can't compare this to WoW. The UI engine of EQ2 is just horrible performance wise.
The rule of thumb is that every additional window you have on screen reduces your performance, even if it's just empty. However, the biggest performance hit are then fonts, in particular if you use the smooth fonts option which is enabled by default. That's due to the way the EQ2 UI engine works, it is just incredibly wasteful in how it renders the UI, in particular fonts with shadows. I estimate that depending on your system speed, every chat window you have open which is filled with text costs you 10-20 fps.
Many releases ago I had packaged high-performance fonts with the UI that did not cause this performance hit but users did not like it.
Another important performance factor is windowed mode. Only moving the mouse cursor in windowed mode will probably cut your fps in half if not more. Don't use the mouse if you play in windowed mode.
So, to summarize: ProfitUI in the default setup costs more resources than the default UI, simply because it displays more things on the screen (even though it takes less space for that than the Default UI). To increase performance hide windows when you don't need them. Set your chat window to hide completely unless you mouse over. Same for other windows. You will see your performance go up considerably.
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