Custom DarqUI windows use default clickthrough behavior, unless elements are added to the window that prevent clickthrough. Detrimental Effects doesn't have anything extra in the body of the window, so I'm not sure why clickthrough is not working for you.
Try this: check for updates with the DarqUI utility and scroll down to Detrimental Effects in the list. Right-click the line and "Use game default" then restart the game. Does the default Detrimental Effects window behave more like you expect?
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