You may want to play around with the full-screen resolution setting in the Options (Alt+O) window. You can change the resolution of the game back to 1080 without affecting the rest of the programs on your computer. Since increasing the game window resolution doesn't actually change how much of the 3D world you can see, the net effect is to enlarge the UI with the only downside of somewhat lower rendering quality of the 3D world. Note that when you toggle the game to windowed mode, it will fall back on the higher resolution in your Windows settings so the UI will go back to being tiny.
Otherwise, the DarqUI group window can be scaled up, the raid window has larger text than the default, you can scale up the maintained effects, spell effects and detrimental effects windows and the NPC casting bar. Hotbars scale up natively, but the "cooldown" text scales up as you resize the DarqUI version. Your bank/inventory/vault slots can all be scaled up or down at the same time using a setting on the Bags tab of the utility.
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