I dual box using two PCs with two monitors. It is possible to run two instances on one machine. Unless your machine is REALLY tweaked it will be borderline unplayable even with all graphic setting at minimum if you try to run them side by side. If your machine is pretty tweaked, your best bet would be to alt-tab between the two instances so only one has to be rendered at a time.
If anyone is interested in swapping dual-boxing tips and tricks, let me know.
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