Well scaling like the hotbar is a hard-set thing (although SOE is going to try to add it to bags). Chat scaling is a different thing, but also hard-set for that window.
The look of a UI should be relatively customizable for any, just replace image files and alter colors in the files themselves.
As for resolutions, there are some for pretty much every resolution around. I suggest you try out the featured ones here: ThorUI, Fetish Nightfall, ProfitUI, etc. and see how you like them.
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