Yes and no.
There are some help windows out there that have space for notes to be added. However, they can only be modified outside of the game.
At this time, I do not believe there is any way to have the ability to make notes in-game (other than jotting them down on paper and either keeping them handy or adding them to the necessary files, of course).
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"Certainty of death! Small chance of success! What are we waiting for?!"
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