This is one of the reasons I ended up getting the 24" Dell Widescreen LCD instead of the 20". 1920x1200 is soooo much better than 1680x1050. Plus my vid card (x800 XL) doesn't support 1680x1050.
I use Fetish at 1920x1200 and after about 20 minutes of playing with the windows from my 1280x1024 setup everything was fine.
Oh, but in Windows, I did have to go from 96DPI to 120DPI so that I could read text
But wow, the Start button is so HUGE!